Experimental Obesity in the Dog

Experimenters in the field of obesity are aware of the controversy which still exists concerning the relative importance of lesions of the hypophysis and of the hypothalamus as causes of experimental obesity. Frohlich (1) and Crowe, Cushing and Homans (2) are among those who attributed to lesions of the hypophysis a dominant role. 14schner (3), Erdheim (4), Bailey and Bremer (5), Camus and Roussy (6), Smith (7), Grafe and Grtinthal (8), Economo (9) and others have declared that lesions of the hypothalamus alone may give rise to obesity. In the opinion of the authors, analysis of the literature yields evidence which supports the interpretation that either a lesion of the hypophysis or of the hypothalamus or both together may lead to obesity. Little to how such lesions may cause obesity has been offered. or no explanation as